COVID-19 new variants (17th May 2022)

COVID-19 new variants (17th May 2022)

17th May 2022 Update 
The wet lab study analysis for the Omicron BA.4 and BA.5 sub-variant has been completed. The result shows that Flowflex has the same sensitivity in testing the omicron sub-variant.

7th April 2022 Update
The wet lab study analysis for the Omicron BA.2 sub-variant has been completed and submitted to MOH. As a result, users of Flowflex can be assured that Flowflex has met regulatory requirements in Singapore on the ART ability to detect BA.2. 

4 Feb 2022 Update
Geneva University Hospital has performed a comparison of the performance of the FlowFlex ART against several other brands including Standard Q and Panbio using clinical specimens with Omicron and Delta Variants. 

FlowFlex has a sensitivity of 91.2% against Delta and 88.9% against Omicron variant. 

Panbio has a sensitivity of 67.7% against Delta and 36.1% against Omicron variant. 

Standard Q has a sensitivity of 52.9% against Delta and 22.2% against Omicron variant. 

Source: https://www.medrxiv.org/content/10.1101/2021.12.18.21268018v2.full.pdf

25 Jan 2022 Update
BA.2 newly detected version of Omicron continues to spread around the world. Like the more familiar version of Omicron, BA.2 has a large number of changes -- about 20 --concentrated in the spike protein, the part of the virus that's targeted by vaccines.

Unlike Omicron BA.1, however, it doesn't cause a certain signature on lab tests called an s-gene target failure, meaning it can look like other SARS-CoV-2 variants on a first screen. That has some calling it "the stealth variant."

Clinical studies for both BA.1 and BA.2 have been completed and submitted to MOH. Users of the FlowFlex ART are assured that Omicron variants do not have an impact on the performance of the ARTs. 

10 Dec 2022 Update
Wet lab study for Omicron variant (B.1.1.529 or BA.1) has been completed and submitted to MOH. As a result, users of the FlowFlex can be assured that the FlowFlex has fulfilled regulatory requirements in Singapore.

29th Nov 2022 Update
Computer simulations known as silico have been conducted and we do not expect any negative impact of the Omicron on the performance of the FlowFlex. MOH has received our in silico analysis report. Download the report here

There is no obvious difference observed when testing with different nucleocapsid protein recombination antigens (Alpha, Beta, Gamma, Delta, Epsilon, Zeta, Eta, Theta, lota, Kappa, Lambda, Mu and Delta plus) basing on these different variants of SARS-CoV-2. The Omicron variant, by theoretical analysis of the mutations in the nucleocapsid protein, should not interfere the detection by the  Flowflex SARS-CoV-2 Antigen Rapid Test. So we do not anticipate that these variants, including Omicron, will have any effect on test performance.